The value of putaminal diffusion imaging versus 18-fluorodeoxyglucose positron emission tomography for the differential diagnosis of the Parkinson variant of multiple system atrophy.
Identifieur interne : 000378 ( Main/Exploration ); précédent : 000377; suivant : 000379The value of putaminal diffusion imaging versus 18-fluorodeoxyglucose positron emission tomography for the differential diagnosis of the Parkinson variant of multiple system atrophy.
Auteurs : Simon Baudrexel [Allemagne] ; Carola Seifried ; Bianca Penndorf ; Johannes C. Klein ; Marcus Middendorp ; Helmuth Steinmetz ; Frank Grünwald ; Rüdiger HilkerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Diagnosis, Differential, Diffusion Magnetic Resonance Imaging (methods), Female, Fluorodeoxyglucose F18 (diagnostic use), Humans, Male, Middle Aged, Multiple System Atrophy (pathology), Multiple System Atrophy (radionuclide imaging), Parkinsonian Disorders (pathology), Parkinsonian Disorders (radionuclide imaging), Positron-Emission Tomography (methods), Putamen (pathology).
- MESH :
- chemical , diagnostic use : Fluorodeoxyglucose F18.
- methods : Diffusion Magnetic Resonance Imaging, Positron-Emission Tomography.
- pathology : Multiple System Atrophy, Parkinsonian Disorders, Putamen.
- radionuclide imaging : Multiple System Atrophy, Parkinsonian Disorders.
- Aged, Aged, 80 and over, Diagnosis, Differential, Female, Humans, Male, Middle Aged.
Abstract
Differentiating the Parkinson variant of multiple system atrophy (MSA-P) from idiopathic Parkinson's disease (PD) and other forms of atypical parkinsonism can be difficult because symptoms overlap considerably. 18-Fluorodeoxyglucose positron emission tomography (FDG-PET) is a powerful imaging technique that can assist in the diagnosis of MSA-P via detection of putaminal and cerebellar hypometabolism. Recent studies suggest that diffusion-weighted imaging (DWI) might be of similar diagnostic value, as it can detect microstructural damage in the putamen by means of an increased mean diffusivity (MD). The aim of this study was a direct comparison of DWI and FDG-PET by using both methods on the same subject cohort. To this end, combined DWI and FDG-PET were employed in patients with MSA-P (n = 11), PD (n = 13), progressive supranuclear palsy (n = 8), and in 6 control subjects. MD values and FDG uptake ratios were derived from volumetric parcellations of the putamen and subjected to further analysis of covariance (ANCOVA) and receiver operating characteristics analyses. MSA-P was found to be associated with an increased posterior putaminal MD (P < 0.001 in all subgroup comparisons) that correlated strongly with local reductions in FDG uptake (r = -0.85, P = 0.002). DWI discriminated patients with MSA-P from other subgroups nearly as accurately as FDG-PET (area under the curve = 0.89 vs 0.95, P = 0.27 [pooled data]). Our data suggest a close association between the amount of putaminal microstructural damage and a reduced energy metabolism in patients with MSA-P. The clinical use of DWI for the differential diagnosis of MSA-P is encouraged.
DOI: 10.1002/mds.25749
PubMed: 24243813
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000672
- to stream PubMed, to step Curation: 000672
- to stream PubMed, to step Checkpoint: 000380
- to stream Ncbi, to step Merge: 003E25
- to stream Ncbi, to step Curation: 003E25
- to stream Ncbi, to step Checkpoint: 003E25
- to stream Main, to step Merge: 000378
- to stream Main, to step Curation: 000378
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The value of putaminal diffusion imaging versus 18-fluorodeoxyglucose positron emission tomography for the differential diagnosis of the Parkinson variant of multiple system atrophy.</title><author><name sortKey="Baudrexel, Simon" sort="Baudrexel, Simon" uniqKey="Baudrexel S" first="Simon" last="Baudrexel">Simon Baudrexel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany; Brain Imaging Center, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany; Brain Imaging Center, Goethe University Frankfurt am Main, Frankfurt am Main</wicri:regionArea><wicri:noRegion>Frankfurt am Main</wicri:noRegion><wicri:noRegion>Frankfurt am Main</wicri:noRegion><wicri:noRegion>Frankfurt am Main</wicri:noRegion></affiliation></author><author><name sortKey="Seifried, Carola" sort="Seifried, Carola" uniqKey="Seifried C" first="Carola" last="Seifried">Carola Seifried</name></author><author><name sortKey="Penndorf, Bianca" sort="Penndorf, Bianca" uniqKey="Penndorf B" first="Bianca" last="Penndorf">Bianca Penndorf</name></author><author><name sortKey="Klein, Johannes C" sort="Klein, Johannes C" uniqKey="Klein J" first="Johannes C" last="Klein">Johannes C. Klein</name></author><author><name sortKey="Middendorp, Marcus" sort="Middendorp, Marcus" uniqKey="Middendorp M" first="Marcus" last="Middendorp">Marcus Middendorp</name></author><author><name sortKey="Steinmetz, Helmuth" sort="Steinmetz, Helmuth" uniqKey="Steinmetz H" first="Helmuth" last="Steinmetz">Helmuth Steinmetz</name></author><author><name sortKey="Grunwald, Frank" sort="Grunwald, Frank" uniqKey="Grunwald F" first="Frank" last="Grünwald">Frank Grünwald</name></author><author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24243813</idno><idno type="pmid">24243813</idno><idno type="doi">10.1002/mds.25749</idno><idno type="wicri:Area/PubMed/Corpus">000672</idno><idno type="wicri:Area/PubMed/Curation">000672</idno><idno type="wicri:Area/PubMed/Checkpoint">000380</idno><idno type="wicri:Area/Ncbi/Merge">003E25</idno><idno type="wicri:Area/Ncbi/Curation">003E25</idno><idno type="wicri:Area/Ncbi/Checkpoint">003E25</idno><idno type="wicri:Area/Main/Merge">000378</idno><idno type="wicri:Area/Main/Curation">000378</idno><idno type="wicri:Area/Main/Exploration">000378</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The value of putaminal diffusion imaging versus 18-fluorodeoxyglucose positron emission tomography for the differential diagnosis of the Parkinson variant of multiple system atrophy.</title><author><name sortKey="Baudrexel, Simon" sort="Baudrexel, Simon" uniqKey="Baudrexel S" first="Simon" last="Baudrexel">Simon Baudrexel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany; Brain Imaging Center, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany; Brain Imaging Center, Goethe University Frankfurt am Main, Frankfurt am Main</wicri:regionArea><wicri:noRegion>Frankfurt am Main</wicri:noRegion><wicri:noRegion>Frankfurt am Main</wicri:noRegion><wicri:noRegion>Frankfurt am Main</wicri:noRegion></affiliation></author><author><name sortKey="Seifried, Carola" sort="Seifried, Carola" uniqKey="Seifried C" first="Carola" last="Seifried">Carola Seifried</name></author><author><name sortKey="Penndorf, Bianca" sort="Penndorf, Bianca" uniqKey="Penndorf B" first="Bianca" last="Penndorf">Bianca Penndorf</name></author><author><name sortKey="Klein, Johannes C" sort="Klein, Johannes C" uniqKey="Klein J" first="Johannes C" last="Klein">Johannes C. Klein</name></author><author><name sortKey="Middendorp, Marcus" sort="Middendorp, Marcus" uniqKey="Middendorp M" first="Marcus" last="Middendorp">Marcus Middendorp</name></author><author><name sortKey="Steinmetz, Helmuth" sort="Steinmetz, Helmuth" uniqKey="Steinmetz H" first="Helmuth" last="Steinmetz">Helmuth Steinmetz</name></author><author><name sortKey="Grunwald, Frank" sort="Grunwald, Frank" uniqKey="Grunwald F" first="Frank" last="Grünwald">Frank Grünwald</name></author><author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Diagnosis, Differential</term><term>Diffusion Magnetic Resonance Imaging (methods)</term><term>Female</term><term>Fluorodeoxyglucose F18 (diagnostic use)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (pathology)</term><term>Multiple System Atrophy (radionuclide imaging)</term><term>Parkinsonian Disorders (pathology)</term><term>Parkinsonian Disorders (radionuclide imaging)</term><term>Positron-Emission Tomography (methods)</term><term>Putamen (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Fluorodeoxyglucose F18</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diffusion Magnetic Resonance Imaging</term><term>Positron-Emission Tomography</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Multiple System Atrophy</term><term>Parkinsonian Disorders</term><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Multiple System Atrophy</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Differentiating the Parkinson variant of multiple system atrophy (MSA-P) from idiopathic Parkinson's disease (PD) and other forms of atypical parkinsonism can be difficult because symptoms overlap considerably. 18-Fluorodeoxyglucose positron emission tomography (FDG-PET) is a powerful imaging technique that can assist in the diagnosis of MSA-P via detection of putaminal and cerebellar hypometabolism. Recent studies suggest that diffusion-weighted imaging (DWI) might be of similar diagnostic value, as it can detect microstructural damage in the putamen by means of an increased mean diffusivity (MD). The aim of this study was a direct comparison of DWI and FDG-PET by using both methods on the same subject cohort. To this end, combined DWI and FDG-PET were employed in patients with MSA-P (n = 11), PD (n = 13), progressive supranuclear palsy (n = 8), and in 6 control subjects. MD values and FDG uptake ratios were derived from volumetric parcellations of the putamen and subjected to further analysis of covariance (ANCOVA) and receiver operating characteristics analyses. MSA-P was found to be associated with an increased posterior putaminal MD (P < 0.001 in all subgroup comparisons) that correlated strongly with local reductions in FDG uptake (r = -0.85, P = 0.002). DWI discriminated patients with MSA-P from other subgroups nearly as accurately as FDG-PET (area under the curve = 0.89 vs 0.95, P = 0.27 [pooled data]). Our data suggest a close association between the amount of putaminal microstructural damage and a reduced energy metabolism in patients with MSA-P. The clinical use of DWI for the differential diagnosis of MSA-P is encouraged.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Grunwald, Frank" sort="Grunwald, Frank" uniqKey="Grunwald F" first="Frank" last="Grünwald">Frank Grünwald</name><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name><name sortKey="Klein, Johannes C" sort="Klein, Johannes C" uniqKey="Klein J" first="Johannes C" last="Klein">Johannes C. Klein</name><name sortKey="Middendorp, Marcus" sort="Middendorp, Marcus" uniqKey="Middendorp M" first="Marcus" last="Middendorp">Marcus Middendorp</name><name sortKey="Penndorf, Bianca" sort="Penndorf, Bianca" uniqKey="Penndorf B" first="Bianca" last="Penndorf">Bianca Penndorf</name><name sortKey="Seifried, Carola" sort="Seifried, Carola" uniqKey="Seifried C" first="Carola" last="Seifried">Carola Seifried</name><name sortKey="Steinmetz, Helmuth" sort="Steinmetz, Helmuth" uniqKey="Steinmetz H" first="Helmuth" last="Steinmetz">Helmuth Steinmetz</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Baudrexel, Simon" sort="Baudrexel, Simon" uniqKey="Baudrexel S" first="Simon" last="Baudrexel">Simon Baudrexel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000378 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000378 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:24243813
|texte= The value of putaminal diffusion imaging versus 18-fluorodeoxyglucose positron emission tomography for the differential diagnosis of the Parkinson variant of multiple system atrophy.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24243813" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |